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phenobarbital will reduce the extent or outcome of olanzapine/samidorphan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Solid CYP3A4 inducers minimize amounts of olanzapine and samidorphan by~50% and ~seventy five% respectively.phenobarbital will minimize the extent or result of bosentan by impact